HTA101: Intervention Research and Clinical Trials

presented by Prof Danie van Zyl

HTA101 Course Summary

Intervention research is research undertaken to develop new or improved healthcare interventions and to evaluate the effectiveness of pharmacologic interventions. This is considered to be the most reliable evidence in healthcare research. In a clinical trial setting, the researcher aims to explore whether a medical strategy, a treatment or a device is safe and effective for humans. Clinical trials produce the best data available for healthcare decision making by utilising stringent scientific standards and protocols in the design and development of intervention research.

Learning Outcomes

In this module you will be able to develop tools to evaluate the most current medical research findings, use the skills developed to apply specific research findings to your own setting or patient population by calculating and interpreting the results.

  • Understand the crucial issues regarding validity requirements for designing and developing protocols for intervention research as well as deciding on the appropriate outcome measures and their interpretation. This includes the following:
    • Understanding RCT (randomised controlled trials) and other trial design and clinical endpoints,
    • Validity issues: Randomisation, allocation concealment, blinding and completeness of follow-up
    • Clinical trial result interpretation: Risk, Rate, Relative Risk Reduction, Absolute Risk Reduction, NNT and NNH, p-values, Confidence Interval (CI) and power
    • Superiority, Non-inferiority, Equivalence and Bioequivalence studies

There will be assignments to complete which will assist in competence evaluation.

Enrolment open

Programme

  • Study Unit 1

    Why RCT (Randomised Controlled Trials)
    Phases of clinical trials
    Good Clinical Practice (GCP)

  • Study Unit 3

    Endpoints
    Validity issues

  • Study Unit 5

    Power
    Subgroup analysis (Multiplicity)
    Interim analysis and stopping rules

  • Study Unit 2

    Erroneous results
    Types of RCT designs
     

  • Study Unit 4

    Interpreting RCT results
    NNT's

  • Study Unit 6

    Revision

  • Study Unit 1

    Why RCT (Randomised Controlled Trials)
    Phases of clinical trials
    Good Clinical Practice (GCP)

  • Study Unit 2

    Erroneous results
    Types of RCT designs

  • Study Unit 3

    Endpoints
    Validity issues

  • Study Unit 4

    Interpreting RCT results
    NNT's

  • Study Unit 5

    Power
    Subgroup analysis (Multiplicity)
    Interim analysis and stopping rules

  • Study Unit 6

    Revision

  • 90 days

    Duration

  • 30 Points

    CPD accreditation

  • 30 - 40 hours

    Study time

  • Fees (excl VAT)

    R3856 Corp Members
    R4097 Stand Members
    R4338 Ind Members
    R4820 Non Members

  • No Webinars

    hosted

Meet the Contributor

Prof Danie van Zyl

Prof Danie van Zyl

Head of the Department of Internal Medicine in the Faculty of Health Sciences at the University of Pretoria

Click on image for bio

Scheduled Events

Please note that dates, topics and presenters are subject to change.

Feb
8
Wed
8:30 am Virtual CPD – 8 February 2023 (P...
Virtual CPD – 8 February 2023 (P...
Feb 8 @ 8:30 am – 10:15 am
Virtual CPD - 8 February 2023 (POSTPONED from 31/01)
Programme 08h55: Login and sound check 09h00: Reaching remission in theory and practicePresented by: Dr Elsa van Duuren (Rheumatologist) 10h05: Wrap up Link to register Thank you to Eli Lilly for providing the unconditional educational sponsorship,…
Feb
9
Thu
8:30 am Virtual CPD – 9 February 2023 @ Zoom - link to register available in the invitation
Virtual CPD – 9 February 2023 @ Zoom - link to register available in the invitation
Feb 9 @ 8:30 am – 10:30 am
Virtual CPD - 9 February 2023 @ Zoom - link to register available in the invitation | Sandton | Gauteng | South Africa
Programme 08h55: Login and sound check 09h00: Tba Presented by: Tba (Tba) 10h05: Wrap up Link to register (Tbc) Attendance free for PTCMA members and HPCSA Medical Practitioners only – not open for Non-Members unless…
Feb
10
Fri
8:30 am Virtual CPD – 10 February 2023
Virtual CPD – 10 February 2023
Feb 10 @ 8:30 am – 10:15 am
Virtual CPD - 10 February 2023
Programme 08h55: Login and sound check 09h00: Tba Presented by: Tba (Tba) 10h05: Wrap up Link to register (Tbc) Attendance free for PTCMA members and HPCSA Medical Practitioners only – not open for Non-Members unless…

Latest Newsletter

Find us on