Manie qualified as doctor at the University of Stellenbosch and worked as primary care doctor in a deep rural hospital and district health services for 40 000 lives in the Eastern Cape of South Africa for a period of four years. He managed the integrated services for this district and hospital for 2.5 years. He then returned to Tygerberg Hospital to assume the role of clinician and medical superintendent for four years.

He supported and was involved in the process towards an integrated Medical Association for South Africa and held positions in the Federal Council and in IPA based organisations in South Africa at Executive level, for a period of 8 years.  He established and all-primary care doctors Inclusive IPA in Mossel Bay and was instrumental in setting up IPA’s in surrounding towns in the Southern Cape.

He spent nine years in private general practice  and three years in a teaching role in Family Medicine at Helderberg Hospital. He established an off-site Faculty of Health Sciences training centre in the Helderberg Basin for final year medical students and registrars in Family Medicine and a private research unit for phase 3 trials in the hospital as well as an HIV clinic. Manie was Managed Care coordinator for Openplan Medical Scheme and was active in a pay for performance system for General Practitioners and in establishing a profiling system for specialists.

He moved to Metropolitan Health as Head of Clinical Governance, GM of the Product Development section of Managed Care for Metropolitan Health Risk as head of the corporate Health Technology Assessment function for Metropolitan Health. He led and took active part in the Drugs and Therapeutics committee of the entity.  He was on the Executive Committee of the Medical Advisors Group and was Chairman of the Medical Advisors Group for four years.  He presently consults to MMI Health on machine learning, genetics and the HTA and to a company that translates biological data to positive health outcomes.

He serves as Associate Professor at the University of Stellenbosch Business School as part of the MBA in Health Care Leadership. He also teaches health technology assessment and pioneered a Post Basic Certificate course in Health Technology Assessment at the University of Stellenbosch in 2010. In 2015 this evolved to the first blended, largely internet based, post basic certificate course in Health Technology Assessment in the country. Manie is an advisor and supervisor for MBA students’ final research assignments on various health topics.